Brief Introduction

Synonyms---Botanical Name: Schisandra chinensis (Turcz.) Baill., Botanical Syn.:Kadsura chinensis - Turcz., Maximowiczia chinensis - (Turcz.) Rupr., Schisandra japonica - (Siebold. & Zucc. ex A. Gray.) Hance.,Kadsura japonica (L.) Dunal,Schidandra sphenanthera Rehd.et Wils.Common name: Schisandra, Schizandra, Five-Flavour fruit, Wuweizi (Chinese: 五味子), Magnolia Vine

Schisandrol A (Schidandrin, Schisandrin B, Garma-schisandrin, Gomisin N)

Chemical Name:7-dimethyl-ethoxy-stereoisomer benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole,5,6,7,8-tetrahydro-1,2,3,13-tetram; or 5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, stereoisomer Benzo [3,4] cycloocta [1,2-f][1,3]benzodioxole

Cas No.: 61281-37-6

Molecular Formula: C23H28O6

Mol. Wt.:400.46

Molecular Structure:

Schisandra chinensis(五味子in Chinese, pinyin: wǔ wèi zi, literally "five flavor berry") is a deciduous woody vine native to forests of Northern China, Korea and the Russian Far East. Its Chinese name comes from the fact that its berries possess all five basic flavors: salty, sweet, sour, pungent (spicy), and bitter. Sometimes it is more specifically called běi wǔ wèi zi (Chinese: 北五味子); literally "northern five flavor berry") to distinguish it from another traditionally medicinal schisandraceous plant Kadsura japonica that grows only in subtropical areas, it is more specifically called Nán wǔ wèi zi ((Chinese: 南五味子). The plant likes some shade with moist, well-drained soil. The species itself is dioecious, thus flowers on a female plant will only produce fruit when fertilized with pollen from a male plant.

Schisandra fruits (berries),which are the small, red, dried, ripe fruits of Schisandra chinensis, are used in traditional Chinese medicine, where it is considered one of the 50 fundamental herbs.The fruit is harvested in autumn, and then steamed before being dried in the sun.

In traditional Chinese medicine, Schisandra fruit (berry)is classified as an adaptogen, an herb that regulates and normalizes the functions of the body and increases its resistance to stress. The active ingredients in schizandra include substances called schizandrins as well as vitamins C and E. Schizandrins have been found to act as tonics for the liver, lungs and kidneys while balancing the immune system, normalizing nervous system function and aiding digestion. Schizandra has also been shown to have anti-oxidants, anti-bacterial and anti-depressant properties. It isbelieved to:

1. Astringe Lung Qi and nourish the Kidneys
2. Restrain the essence and stop Diarrhea--astringent Kidneys
3. Arrest excessive sweating from Yin or Yang deficiency
4. Calm the Spirit by tonification of Heart and Kidney
5. Generate body fluids and alleviate thirst

In Chinese Medicine, Schisandra berry is used mainly for conditions of the digestive tract such as intestinal inflammation, and also for insomnia, enuresis, pollakisuria, nightly ejaculation, coughs, chronic diarrhea, dyspnea, insomnia, spontaneous outbreaks of sweating, hepatitis, neurasthenia and anxiety states. In Russia, schizandrin is a registered medicine for problems with vision, since the herb has been found to prevent eye fatigue and increase visual acuity. It also assists in the body’s detoxification process after the use of alcohol, cigarettes and other drugs.

In traditional Chinese medicine, they are most often used in dried form, and boiled to make a tea. Medicinally it is used as a tonic and restorative adaptogen with notable clinically documented liver protecting effects.

Schisandra fruit (berry) contains lignans, including dibenzocyclooctene derivative lignans (about 2% by weight), known totally as schisandrins, with the main constituents being:

1. Schisandrin (Schisandrin B, Gomisin N, Schisandrol A, garma-schisandrin (the racemic form of schisandrin B), Schisandrol B (gomisin A)), gomisins D to J, K1 to K3, L1 and L2, M1 and M2, O, P to T, the gomisins present to some extent as esters, amony them those of angelic acid, benzoic acid and acetic acid

2. Schisandrin A (deoxyschizandrin), Schisandrin C

3. Additional lignans with other parent substances, including pregomisin,

Research teams have given the Schisandra lignans several names over the years, which we should make clear. The following synonyms apply:

* schisandrin = schisandrol A = wuweizi alcohol A=Schisandrin B=Garma-schisandrin=Gomisin N = wuweizisu B = wuweizisu = wuweizichun A

* schisandrin A = deoxyschisandrin = wuweizisu A

* gomisin A = schisandrol B = wuweizichun B

Other constituents include [beta]-carboline alkaloids, cyclic dipeptides, Vitamin C, Volatile oil: Containing among others, alpha- and beta- chamigrene, chamigrenal, sesquicarene, (+)-ylangene, fatty oil: Chief fatty acids oleic acid and linoleic acid.

Schidandrins are the primary hepatoprotective (liver protecting) and immuo-modulating constituents in schisandra fruit (berry), which act as radical scavengers and promoting liver regeneration. Anti-inflammatory and tumor-inhibiting characteristics have also been demonstrated. Schizandrol A is said to be neuroleptic, anticonvulsive and sedative in effect. And Schisandra fruits (berries) are believed to bring about a non-specific increase in physical performance ability, and to be anthelminthic in effect.

The Schisandra Berry Extract used in dietary supplements is derived from the fruits(Berries) of the plant Schidandra (Schisandra chinensis (Turcz.) Baill.).

Benefits

•Hepatoprotective (liver protecting) Effects (Promoting liver regeneration)

•Immuno-modulating Effects (Radical scavengers)

•Anti-inflammatory Effects

• Anthelminthic Effects

•Tumor-inhibiting Effects

•Neuroleptic, anticonvulsive and sedative Effects

• Increasing physical performance Effect (Non-Specific)

Mechanism

Referring to the above information.

Safety

Schisandra berry Extract is safe; no side effects have been reported to date.

But it should not be used by pregnant women.

Dosage

•  The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day).
•  Consult physicians for different condition specifics.

GNI’s Schisandra berry Extract Features and Benefits:

Schisandra berry Extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from  seeds.

•  Produced with pure water only

•  High purity: over 9%

•  NO solvent - residual free

•  Pesticide-free

•  Brown-yellow in appearance

•  High solubility in water

•  High anti-bacteria, and longer shelf life

Product Specifications:

1%, 2%, 5%, 9% Schisandrins HPLC,

10:1